3, 17-Dihydroxy-Delta-5-Etiocholane-7-One Diethylcarbonate (also called A7-E) is a chemical compound which has shown considerable promise as a fat burner. It increases the basal metabolic rate (BMR) and enhances the function of the thyroid gland. It increases the levels of the thyroid hormone T3 which increases heat generation through non-shivering thermo genesis. It increases the level of malic enzyme leading to the production of oxaloacetate which is rate limiting (its dearth lowers the rate of reaction) in fat metabolism. A7-E also stimulates mitochondrial energy production using fat.

Caffeine is a stimulant that is used to stay awake and it gives mental alertness from fatigue. This is used as an adjunct for pain relief and also as energy accelerates. Caffeine is regularly used in products like Biotest Hot-Rox as a cheap ingredient to give the appearance of the creation of energy in the body. Caffeine increases the mental alertness by offering the required energy for exercise training and weight loss. Caffeine cannot be considered as a mere stimulant as it reaches deep into muscles and provides power that is long lasting. Caffeine taken before any work out is also great as it fights the fatigue and keeps the person ready for the workout. Dieters also find caffeine as the solution as they feel sluggish. This is a no-calorie stimulant and does its job effectively and quickly. Caffeine anhydrous is found even in one or two coffee cups. However, this limitation is recommended as excess caffeine may result in irritability, rapid heart beat, nervousness and sleeplessness.

Forskolin is an ingredient found in the Indian coleus plant, also known as Coleus forskohlii. It is a labdane diterpene that is currently very popular as a nutritional supplement, predominantly in the body building circles. The ability to raise the levels of cyclic adenosine monophosphate, cAMP, by deploying the enzyme adenylyl cyclase in the cAMP dependent pathway, made forskolin very important. Further benefits of forskolin include reduction of urinary tract infections, in connection with rolipram inhibition of colon cancer spreading, stimulation of proper tanning response with increased skin resistance to sun burns, reduction of intraocular pressure in glaucoma cases and apparently assistance in weight loss programs. Forskolin was observed to increase bone and lean mass as well as testosterone levels in clinical trials conducted with human test subjects, this is why it was added to the Biotest Hot-Rox Extreme Formula.

Piperine is the substance responsible for the spiciness of pepper. It is of alkaloid in nature and is found in the plant species of the genus Piper of the Piperaceae family. The black pepper, Piper nigrum, has been utilized in the medicine system of Ayurveda for the treatment and management of different illnesses and diseases. Piperine has been found out to be more than just a spice component. In humans, piperine was observed to inactivate some enzymes that are crucial in metabolism of some drugs. The study of G. Shoba, T. Joseph, M. Majeed, R. Rajendran, and P.S. Srinivas of St. John’s Medical College in India about the influence of piperine on the pharmacokinetics of curcumin in animals and humans showed intriguing results. Curcumin is a substance found in the spice turmeric that has antioxidant and anti-inflammatory properties. Piperine increases the bioavailability of curcumin potentiating its effect in the body.

Yohimbine HCL, sometimes called yohimbine hydrochloride, yohimbe, or yohimbe bark, is an herbal supplement which serves as a stimulant and possible aphrodisiac for users. Yohimbine has also been shown to be successful in treating erectile dysfunction and impotence in men. It may serve to boost the sex drive of those who take it for aphrodisiac purposes. Some people are recommended to take yohimbine to combat their lower sex drives caused by antidepressants. Yohimbine has also been shown to help blood pressure levels and assist in weight loss. For these reasons, yohimbine is a popular supplement amongst athletes as well as many others wishing to improve their health.